Drug Screening with Primary Cells
"Cultured primary cells, blood platelets and neurons all possess characteristics that often represent in vivo physiology better than immortalized cell lines. Assays in these cell types could give a more accurate prediction of the activity of compounds in in vivo models and in the clinic, and thus could contribute to a decrease in attrition in the whole process of small-molecule drug discovery".
Guido J.R. Zaman, NV Organon, Molecular Pharmacology Unit, quoted in Drug Discovery Today, Vol. 9, No. 19, October 2004.
